A methodology is developed for the analysis of diesel engine in-cylinder processes and combustion. Beginning from CAD data of the engine geometry, the methodology involves use of a commercial code AVL FIRE for simulation of suction stroke and an open-source code KIVA-3V for simulation of the closed-valve part of the diesel cycle. For this, an algorithm is first developed to map a generalised three-dimensional Computational Fluid Dynamics (CFD) solution from an unstructured mesh in AVL FIRE to a structured mesh in KIVA-3V to provide initial conditions for the closed-valve simulations. For simulation of diesel combustion process, an integrated KIVA-3V code is developed by incorporating two well-validated models into the standard code: the Shell hydrocarbon auto-ignition model for simulation of diesel auto-ignition under conditions of high temperature and pressure and the Characteristic-time model for simulation of subsequent diesel combustion. The integrated code is validated and calibrated against experimental pressure measurements in a naturally aspirated direct injection diesel engine. These tools are then used for exploring the potential of a constant-speed, turbocharged diesel engine towards emission reduction. The case study involves combustion simulations for exploring multiple injection strategy for the engine concerned. Copyright © 2010 Inderscience Enterprises Ltd.