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C−H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes
L. Massignan, X. Tan, T.H. Meyer, , A.M. Messinis, L. Ackermann
Published in Wiley-VCH Verlag
2020
PMID: 31777143
Volume: 59
   
Issue: 8
Pages: 3184 - 3189
Abstract
The catalytic generation of hypervalent iodine(III) reagents by anodic electrooxidation was orchestrated towards an unprecedented electrocatalytic C−H oxygenation of weakly coordinating aromatic amides and ketones. Thus, catalytic quantities of iodoarenes in concert with catalytic amounts of ruthenium(II) complexes set the stage for versatile C−H activations with ample scope and high functional group tolerance. Detailed mechanistic studies by experiment and computation substantiate the role of the iodoarene as the electrochemically relevant species towards C−H oxygenations with electricity as a sustainable oxidant and molecular hydrogen as the sole by-product. para-Selective C−H oxygenations likewise proved viable in the absence of directing groups. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
About the journal
JournalData powered by TypesetAngewandte Chemie - International Edition
PublisherData powered by TypesetWiley-VCH Verlag
ISSN14337851