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Electrocatalytic C–H phosphorylation through nickel(III/IV/II) catalysis
S.-K. Zhang, A. Del Vecchio, , A.M. Messinis, Z. Lin, L. Ackermann
Published in Elsevier Inc.
2021
Volume: 7
   
Issue: 5
Pages: 1379 - 1392
Abstract
C–H phosphorylation was achieved by Earth-abundant nickel catalysts with waste-free electricity as the redox surrogate. The robust nickela-electrooxidative C–H activation of arenes, heteroarenes, and olefins with diverse phosphonating reagents successfully delivered arylphosphonates, phenylphosphine oxides, and diazaphospholidine oxides of relevance to bioactive compounds and materials. The guanidine-assisted electrooxidative C–P formation avoided chemical oxidants with molecular hydrogen as the sole byproduct. Catalytically relevant nickel(II) and nickel(III) intermediates were isolated and fully characterized by X-ray diffraction analysis. Catalytically relevant nickel complexes were observed by in operando high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) monitoring. Cyclic voltammetry analysis and density functional theory (DFT) calculations provided strong evidence for a nickel(III/IV/II) manifold. © 2021 Elsevier Inc.
About the journal
JournalData powered by TypesetChem
PublisherData powered by TypesetElsevier Inc.
ISSN24519308