The potential impacts of the inverter-interfaced renewable energy resources (IIRERs) on the performance of sequence-based directional relaying schemes (SBDRS) have been investigated in this paper. The directional overcurrent relays such as 67POS, 67NEG, 67ZERO and 32Q have been considered for the investigation. CIGRE-14 bus system with IIRERs along with detailed modeling of inverter control scheme (with and without grid codes) and SBDRS have been done in the PSCAD environment. The mathematical analysis and circuit realization of the IIRERs have been attempted in the paper. The exclusive fault characteristics exhibited by IIRERs cause the conventional SBDRS to mal-operate. Significant change in levels of sequence currents and angular relationships between sequence voltages and currents during faults contributes to relay's unpredictable behavior. The comparative study based on different fault types, fault resistances and interconnecting transformer connections have also been done. The study reveals the impact of non-generalized angular differences between positive sequence voltage and current at the inverter terminal on performance of 67POS. It is found that 67NEG and 32Q mal-operated for all types of unbalanced faults while the 67ZERO can be utilized for grounded fault with delta-star grounded connection of interconnecting transformer. © 2023 Elsevier B.V.