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Force-velocity relation and load-sharing in the linear polymerization ratchet revisited: the effects of barrier diffusion
Published in Springer Science and Business Media Deutschland GmbH
2022
PMID: 35416551
Volume: 45
   
Issue: 4
Abstract
Abstract: We study the velocity-force (V-F) relation for a Brownian ratchet consisting of a linear rigid polymer growing against a diffusing barrier, acted upon by a opposing constant force (F). Using a careful mathematical analysis, we derive the V-F relations in the extreme limits of fast and slow barrier diffusion. In the first case, V depends exponentially on the load F, in agreement with the well-known formula proposed by Peskin, Odell and Oster (1993), while the relationship becomes linear in the second case. For a bundle of two filaments growing against a common barrier, equal sharing of load in the corresponding V-F relation is predicted by a mean-field argument in both limits. However, the scaling behaviour of velocity with the number of filaments is different for the two cases. In the limit of large D, the validity of the mean-field approach is tested, and partially supported by a detailed and rigorous analysis. Our principal predictions are also verified in numerical simulations. Graphic abstract: [Figure not available: see fulltext.]. © 2022, The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature.
About the journal
JournalEuropean Physical Journal E
PublisherSpringer Science and Business Media Deutschland GmbH
ISSN12928941
Open AccessNo