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Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β

Camille Chauvin, Sruthi Vijaya Retnakumar,
Published in Nature

Sun and colleagues describe that, following allergen proteases exposure, the secretion of interleukin-33 is dependent on a novel p40 N-terminal fragment of gasdermin D (GSDMD), whose generation is independent of inflammatory caspase-1 and caspase-11. This event is enabled by the nucleocytoplasmic transport of sequestered IL-33 through Stress Granules (SG) assembly.

About the journal
JournalData powered by TypesetCellular & Molecular Immunology
PublisherData powered by TypesetNature
Open AccessNo