A microfluidic strategy for the encapsulation and stimulus-responsive release of molecules with distinct polarities from the interior of microgels is reported. The approach relies on (i) the generation of a primary O/W emulsion by the ultrasonication method, (ii) MF emulsification of the primary emulsion, and (iii) photopolymerization of the monomer present in the aqueous phase of the droplets, thereby transforming them into microgels. Non-polar molecules are dissolved in oil droplets embedded in the microgels. Polar molecules are physically associated with the hydrogel network. Upon heating, the microgels contract and release polar and non-polar cargo molecules. The approach paves the way for stimuli-responsive vehicles for multiple drug delivery. Poly( N -isopropylacrylamide) microgel particles encapsulated with oil droplets are synthesized using microfluidics. The particles are loaded with molecules of different polarities. A temperature-induced release of the cargo is observed. This has potential for multiple drug delivery systems. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.