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Photocatalytic Hydro Tri/Difluoromethylation of Alkenes with Bench Stable Tri/Difluoromethylating Reagents
Girish Yedase Suresh, Munaifa Arif, , Veera Yatham Reddy
Published in American Chemical Society
2023
Volume: 25
   
Issue: 33
Abstract
Herein, we demonstrate the synthesis and characterization of bench stable tri/difluoromethylating reagents and their potential applications in redox neutral hydro tri/difluoromethylation of alkenes enabled by visible light. The new tri/difluoromethylating reagents are obtained on a gram-scale through simply cyclocondensation of commercially available anthranilamide with phenyltrifluoro or difluoromethyl ketone. Preliminary mechanistic studies indicated that a canonical photoredox catalytic cycle is being operative. DFT studies support this and further reveal that deprotonation occurs before radical cleavage. DFT studies also show that the better yield with HCF2 reagent is attributed to the favorable expulsion of the corresponding radical moiety. © 2023 American Chemical Society.
About the journal
JournalOrganic Letters
PublisherAmerican Chemical Society
ISSN15237060