Nondestructive evaluation (NDE) can provide invaluable information about the condition of tendons in post-Tensioned and cable-stayed bridges, which can facilitate preventative actions to mitigate further deterioration. To date, the use of nondestructive testing methods for routine maintenance of bridges has been relatively low, partly due to limitations of available technologies but mainly owing to a lack of know-how regarding existing NDE techniques and guidelines. This study aims to develop guidelines to assist bridge owners and engineers in selecting the most appropriate NDE method or combination of methods for assessing the condition of in-service post-Tensioning and stay cable systems. An extensive experimental study is conducted on a full-scale post-Tensioned girder specimen and four large-scale stay cable specimens to evaluate the performance of various NDE methods in detecting location and severity of numerous strand and grout defects. Decision metrics are developed considering multiple criteria such as precision, accuracy, ease of use, inspection requirements, and cost. The decision metrics are intended to facilitate selecting the most appropriate NDE method for assessing a particular defect condition. Overall scores for the tested NDE methods in identifying various defect conditions in different parts of the post-Tensioning and stay cable systems are calculated using a weighted sum model. These scores are used to develop a list of ranked NDE methods for evaluating a particular defect condition within a specific location and for a specific duct material. © 2019 American Society of Civil Engineers.