This work introduces a compact, flexible, and conformal F-slot monopole antenna for detecting cancer in human arm. This put forward antenna is composed of two flexible materials. One material is denim with a dimension 10 × 10 mm2and the other is felt with a dimension 10 × 15 mm2. The structure is integrated with six metamaterial unit cells to enhance its gain, directivity and bandwidth throughout the operating band. The proposed antenna operates over 5.6 - 58.6 GHz with return loss greater than 10 dB. The antenna attains maximum gain of 6 dBi at 43 GHz. The antenna is further attached to a human arm phantom developed in the simulator for obtaining the required signals for imaging a cancerous tissue embedded in the skin layer of the designed phantom. © 2022 IEEE.