Biological Sciences and Engineering

Indian Institute of Technology Palakkad&nbsp;(IIT Palakkad or IIT PKD) is a public autonomous&nbsp;engineering&nbsp;and&nbsp;research&nbsp;institute located in&nbsp;Palakkad,&nbsp;Kerala. It was&nbsp;one of the five new&nbsp;IITs&nbsp;proposed in the&nbsp;2014 Union budget of India. The campus was inaugurated on 3 August 2015. The institute has 94 faculty, 978 students, and 63 non-teaching staffs.

IT Palakkad currently offers four-year Bachelor of Technology (B.Tech) and two years MS programmes in 8 different engineering disciplines including&nbsp;Computer Science, Electrical, Mechanical, Civil among others.

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IIT Palakkad

World University root node

International Immunopharmacology

Erratum: Intravenous immunoglobulin in autoimmune disorders: An insight into the immunoregulatory mechanisms (International Immunopharmacology (2006) 6 (528-534))

Seventh European Workshop on Immune-Mediated Inflammatory Diseases 2012 Noordwijk aan Zee, The Netherlands, 28-30 November 2012 The European Workshop on Immune-Mediated Inflammatory Diseases aims to exchange scientific knowledge and promote the collaboration between various disciplines (rheumatology, dermatology and gastroenterology) among physicians and scientists. This year ophthalmologists and neurologists were also present for the first time. The meeting revolved around the following topics: fibrosis, gene therapy in ophthalmology, functional genomics, challenges in human immunology, environmental factors, diabetes and metabolism, novelties in multiple sclerosis and innate lymphoid cells. The workshop was preceded by a masterclass that covered the last 15 years of IL-17/Th17 research and provided an overview on future therapeutics to battle immune-mediated inflammatory diseases. © 2013 Expert Reviews Ltd.

Expert Review of Clinical Immunology

Immune-mediated inflammatory diseases: Progress in molecular pathogenesis and therapeutic strategies

Journal of Infectious Diseases

Mycobacterium tuberculosis promotes regulatory T-Cell expansion via induction of programmed death-1 ligand 1 (PD-L1, CD274) on dendritic cells

Immunotherapy

Chemokine axis as a therapeutic target to enhance the recruitment of Tregs and treat organ-specific autoimmune and inflammatory diseases

Fulltext

Proceedings of the National Academy of Sciences of the United States of America

Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis

CD4+CD25+Foxp3+ regulatory T cells (Treg) have emerged as a dominant T cell population inhibiting anti-tumor effector T cells. Initial strategies used for Treg-depletion (cyclophosphamide, anti-CD25 mAb...) also targeted activated T cells, as they share many phenotypic markers. Current, ameliorated approaches to inhibit Treg aim to either block their function or their migration to lymph nodes and the tumor microenvironment. Various drugs originally developed for other therapeutic indications (anti-angiogenic molecules, tyrosine kinase inhibitors,etc) have recently been discovered to inhibit Treg. These approaches are expected to be rapidly translated to clinical applications for therapeutic use in combination with immunomodulators. © 2012 Landes Bioscience.

OncoImmunology

Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer

Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoimmune conditions. Despite its successful use in immunopathologies for over two decades, the precise mechanisms underlying the therapeutic benefit have not been fully elucidated. We and others have demonstrated that IVIg inhibits the antigen uptake and presentation by dendritic cells (DC). Here we report that IVIg-mediated inhibition of uptake and processing of antigens is associated with an increased accumulation of lipid as analyzed by flow cytometry and electron microscopy. As accumulation of lipids in DC is known to impart tolerogenic properties, these findings unravel novel link between antibodies and intracellular physiology of innate cells and may further uncover novel immunoregulatory mechanisms of IVIg in auto-inflammatory diseases. © 2012 Elsevier Ltd.

Journal of Autoimmunity

Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: Role of lipid accumulation

AIDS

Toll-like receptor-2 ligand lipomannan from Mycobacterium tuberculosis does not stimulate inflammatory cytokines in dendritic cells

Myeloid dendritic cell dysfunction during primary HIV-1 infection is independent of interaction with GP120

Microorganisms are often covered by a proteinaceous surface layer that serves as a sieve for external molecular influx, as a shield to protect microbes from external aggression, or as an aid to help microbial dispersion. In bacteria, the latter is called the S-layer, in Actinomycetes, the rod-like fibrillar layer, and in fungi, the rodlet layer {[}1]. The self-assembly properties and remarkable structural and physicochemical characteristics of hydrophobin proteins underlie the multiple roles played by these unique proteins in fungal biology.

PLoS Pathogens

Hydrophobins-unique fungal proteins